WebbZIP proteins are transcription factors that consist of three modular functional regions mediating dimerization, DNA binding and transcriptional regulation. The hallmark of these proteins is the bZIP (basic region, leucine zipper) domain, a well-defined motif in eukaryotic proteins (1, 2).The basic region of the bZIP domain, rich in lysines and arginines, … WebFeb 10, 2024 · Combinatorial bZIP dimers display complex DNA-binding specificity landscapes How transcription factor dimerization impacts DNA-binding specificity is …
Leucine zipper - Wikipedia
The Basic Leucine Zipper Domain (bZIP domain) is found in many DNA binding eukaryotic proteins. One part of the domain contains a region that mediates sequence specific DNA binding properties and the leucine zipper that is required to hold together (dimerize) two DNA binding regions. The DNA … See more bZIP transcription factors are found in all eukaryotes and form one of the largest families of dimerizing TFs. An evolutionary study from 2008 revealed that 4 bZIP genes were encoded by the genome of the most recent common ancestor See more • AP-1 fos/jun heterodimer that forms a transcription factor • Jun-B transcription factor See more • bZIP domain entry in the SMART database • bZIP family at PlantTFDB: Plant Transcription Factor Database • Plant bZIP transcription factors Archived 2012-03-20 at the See more ATF1; ATF2; ATF4; ATF5; ATF6; ATF7; BACH1; BACH2; BATF; BATF2; CEBPA; CEBPB; CEBPD; CEBPE; CEBPG; CEBPZ; CREB1; CREB3; CREB3L1; CREB3L2; CREB3L3; CREB3L4; CREB5; CREBL1; CREM; E4BP4; FOSL1; FOSL2; JUN; JUNB; JUND See more WebbZIP proteins are transcription factors that consist of three modular functional regions mediating dimerization, DNA binding and transcriptional regulation. The hallmark of … freaky monday vodafone
Two interacting bZIP proteins are direct targets of COP1 …
WebMar 1, 2002 · The bZIP domain consists of two structural features located on a contiguous α-helix Fig. I [a]: first, a basic region of ∼16 amino acid residues containing a nuclear localization signal followed by an invariant N-x 7-R/K motif that contacts the DNA; and, second, a heptad repeat of leucines or other bulky hydrophobic amino acids positioned … WebFeb 10, 2024 · Combinatorial bZIP dimers display complex DNA-binding specificity landscapes How transcription factor dimerization impacts DNA-binding specificity is poorly understood. Guided by protein dimerization properties, we examined DNA binding specificities of 270 human bZIP pairs. WebThe bZip peptide obtained had only 43% sequence homology to GCN4, but bound specifically to an oligonucleotide containing the TRE site. Truncation of the bZip motif … freakymon launcher download