Websubunit of an RNA-binding protein (RBP) (14). Moreover, DJ-1 binds to PIAS proteins (15), a family of SUMO-1 ligases that modulate the activity of various transcription factors (16). DJ-1 itself is sumoylated at lysine 130 (15). Interestingly, in human and murine cell lines, DJ-1 has been identified as a hydroperoxide-responsive protein, that is WebNov 17, 2024 · Human DJ-1 (PARK7) is a small (20 kDa) protein that belongs to the large, multi-clade DJ-1 (or sometimes DJ-1/PfpI) superfamily. The DJ-1 superfamily is present in most organisms from bacteria to humans, and often several different members of the superfamily can be found in a single species.
DJ-1, a cancer- and Parkinson
Gene The gene PARK7, also known as DJ-1, encodes a protein of the peptidase C56 family. The human gene PARK7 has 8 Exons and locates at chromosome band 1p36.23. Protein The human protein deglycase DJ-1 is 20 kDa in size and composed of 189 amino acids with seven β-strands and nine α-helices in … See more Protein deglycase DJ-1, also known as Parkinson disease protein 7, is a protein which in humans is encoded by the PARK7 gene. See more Under an oxidative condition, protein deglycase DJ-1 inhibits the aggregation of α-synuclein via its chaperone activity, thus functioning as a redox-sensitive chaperone and as … See more PARK7 has been shown to interact with: • CASK, • EFCAB6, and • PIAS2. See more • Overview of all the structural information available in the PDB for UniProt: Q99497 (Protein/nucleic acid deglycase DJ-1) at the See more Defects in this gene are the cause of autosomal recessive early-onset Parkinson's disease 7. See more • Parkinson's disease See more • Cookson MR (Jan 2003). "Pathways to Parkinsonism". Neuron. 37 (1): 7–10. doi:10.1016/S0896-6273(02)01166-2. PMID 12526767. S2CID 14513509. • Bonifati V, Oostra BA, Heutink P (Mar 2004). "Linking DJ-1 to neurodegeneration offers novel insights for … See more WebNov 17, 2024 · The DJ-1 (also called the DJ-1/PfpI, ThiJ/PfpI, or DJ-1/ThiJ/PfpI) superfamily is a structural and functional diverse group of proteins that are present in most … ifec chiro
PARK7/DJ-1 Protein Overview: Sequence, Structure, …
WebThe DJ-1 (also called the DJ-1/PfpI, ThiJ/PfpI, or DJ-1/ThiJ/PfpI) superfamily is a structural and functional diverse group of proteins that are present in most organisms. Many of … WebFeb 19, 2024 · Title: DJ-1 activates the AMPK/mTOR pathway by binding RACK1 to induce autophagy and protect the myocardium from ischemia/hypoxia injury. Gene-based … WebJan 1, 2024 · In humans and plants, this enzyme is termed DJ-1, and it is known to exhibit a variety of cellular functions. Human DJ-1 protects rat neurons against oxidative stress [ 7 ], has chaperone [ 8 ], glyoxalase [ 9 ], and deglycase activity [ 10 ], and forms a scaffold for RNA-associated proteins [ 11 ]. is smb 3 crosplay