WebColorectal cancer (CRC) is the third most common malignancy and a leading cause of cancer-related death worldwide. GEF-H1 is considered a RhoA-specific guanine … WebJan 25, 2024 · Stage 4 colon cancer is classified as either stage 4A, 4B, or 4C. Stage 4A. This stage indicates that the cancer has spread to one distant site, like the liver, lungs, or lymph nodes. Stage 4B ...
Frontiers Blockade of GCH1/BH4 Axis Activates Ferritinophagy to ...
WebSep 19, 2012 · Department of Biological Science, Centre for Colon Cancer, University of South Carolina, Columbia, SC, USA. ... Ferritin heavy chain 1 (FTH1) was identified as a candidate gene, which is involved in iron metabolism and iron depletion significantly decreased the self-renewal of CSCs. We further performed in silico analysis of altered … WebOct 2, 2024 · NRF2 can up-regulate diverse ferroptosis inhibitors, such as NQO1 and FTH1, and sensitize hepatic cancer cells to sorafenib and erastin both in vitro and in vivo. Furthermore, ... Mutations in p53 also protect colorectal cancer cells from the effects of erastin-induced ferroptosis , which may offer a new treatment option. millimeters in an ounce
Novel insights on targeting ferroptosis in cancer therapy
WebSep 21, 2024 · FTH1, a key subunit of ferritin, is involved in a variety of disease signaling pathways. In particular, the expression of FTH1 varies in different diseases. FTH1 was shown to regulate immunity in studies of prostate and breast cancer [37, 38]. FTH1 has been shown to inhibit apoptosis through the JNK signaling pathway activity . WebDec 1, 2024 · The AOM-DSS mouse model is a well-accepted model of colitis-associated colon cancer [].As shown in Fig. 1A, C57BL/6 mice were intraperitoneally administered 12.5 mg/kg AOM followed by 2.5% DSS for five consecutive days. For diet intervention, AOM-DSS mice were fed with a high-fat diet (HFD, D12492) or a control chow diet (CD, … WebSep 22, 2024 · Overexpression of ferritin heavy chain (FTH1) often associates with good prognosis in breast cancer (BCa), particularly in the triple-negative subtype (triple-negative breast cancer).However, the mechanism by which FTH1 exerts its possible tumor suppressor effects in BCa is not known. Here, we examined the bearing of FTH1 … millimeters mercury to atmospheres