Half life of iv zofran
WebAug 17, 2024 · Absence of QT prolongation (perhaps the greatest advantage). ( 26111957) Longer half-life (~40 hours). Superior efficacy compared to ondansetron (especially the 8-mg dosing of ondansetron). 0.25 mg palonosetron IV is a commonly used dose for prevention of chemotherapy-induced nausea and vomiting. ( 26345982) WebNo single dose should exceed 16 mg/dose IV. Dosage may be repeated twice, administered 4 and 8 hours after the initial dose. NOTE: Since 2012, a 32 mg IV single-dose regimen …
Half life of iv zofran
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WebOral. Prophylaxis of chemotherapy-induced nausea and vomiting. Adult: Moderately emetogenic chemotherapy: 8 mg given 0.5-2 hours prior to chemotherapy, followed by 8 mg after 8 or 12 hours. Highly emetogenic chemotherapy: 24 mg as a single dose, given 0.5-2 hours prior to chemotherapy. Child: Moderately emetogenic chemotherapy: 4-11 years 4 … WebClearance and volume of distribution are higher in young (7-12 years) cancer patients, resulting in a mean plasma half-life of 2.5 hours. Plasma clearance is slightly slower in females. Ondansetron clearance decreases and half-life increases in patients with severe hepatic insufficiency.
WebThe usual maximum single dose is 16 milligrams. Older adults are usually prescribed a lower dose to decrease the risk of side effects. Depending on the type of chemotherapy … Webintravenous dose of ZOFRAN was significantly reduced and the serum half-life significantly prolonged in subjects with severe impairment of hepatic function. In patients with moderate or severe impairment of hepatic function, reductions in dosage are therefore recommended and a total daily dose of 8 mg should not be exceeded. This may
WebHalf-life (h) 18-43 M F 84.1 71.8 8 8 125.8 194.4 1.9 1.6 4.7 5.8 105 106 A reduction in clearance and increase in elimination half-life are seen in patients over 75 years 107 of age. In clinical trials with cancer patients, safety and efficacy were similar in patients over WebApr 1, 2024 · Zofran; Zofran ODT; Zuplenz; Descriptions. Ondansetron is used to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy) or radiation …
WebThe half-life of ondansetron after either an 8 mg oral dose or i.v. dose was approximately 3 to 4 hours and may be extended to 6 to 8 hours in the elderly. ... The clearance of an 8 mg intravenous dose of ondansetron was significantly reduced and the serum half-life significantly prolonged in subjects with severe impairment of hepatic function ...
WebIn patients 1 month to 4 months of age, a longer half-life was observed due to the higher volume of distribution in this age group. In normal volunteers (19 to 39 years old, n = 23), … bow with ukeWebMay 23, 2024 · The half-life of a drug is an estimate of the time it takes for the concentration or amount in the body of that drug to be reduced by exactly one-half (50%). The symbol for half-life is t½. For example, if … bow woodworking productsWebFeb 17, 2024 · Duration of Action Oral, IV: 24 hours Half-Life Elimination Neonates (PMA: 37 to 44 weeks): ~3 hours (Ward 2010) Children and Adolescents (Kearns 2008): IV (2 to 16 years of age): 1.22 ± 0.68 hours; Oral (5 to 16 years of age): 1.27 ± 1.29 hours Adults: 1 hour; increased to 3.5 to 10 hours with CYP2C19 deficiency Protein Binding bow woods listWebIt may take a longer time for Zofran oral tablets to work than Zofran ODT or IV forms. ... The half-life of an 8-mg tablet or IV dose of ondansetron is around three to four hours. However, in older adults with decreased liver function, the half-life may be around five and a half hours. As it takes four to five half-lives for a drug to be ... gun shop victor nyWebCalculated elimination half-life of ondansetron was 1.84 ± 0.58 h (intravenous), 1.18 ± 0.27 h (oral) and 3.17 ± 0.53 h (subcutaneous). The calculated elimination half-life of … gun shop vincennes indianaWebOct 26, 2024 · The recommended adult intravenous dosage of ZOFRAN is 4 mg undiluted administered intravenously in not less than 30 seconds, preferably over 2 to 5 minutes, … gun shop wadsworth ohioWebFeb 8, 2024 · The disposition of ondansetron following oral, intramuscular (IM) and intravenous (IV) dosing is similar with a terminal half life of about 3 hours and steady state volume of distribution of about 140 L. Equivalent systemic exposure is achieved after IM and IV administration of ondansetron. bow work bench