Plk1 antibody cell signaling
Webb5 apr. 2024 · JH295 irreversibly inhibits cellular Nek2 without affecting the mitotic kinases, Cdk1, Aurora B, or Plk1. It inhibits WT Nek2 in cells with an IC 50 of ~1.3 μM, whereas it has little effect on the C22V mutant. The inhibition of cellular Nek2 by JH295 occurs via alkylation of Cys22 and is not an indirect effect of inhibiting kinases that ... WebbHIF-1alpha/HIF1A Mouse Monoclonal Antibody -20ºC保存，需避免反复冻融。 Western一抗稀释液-20℃或4℃保存，一年有效，Western一抗稀释液优先推荐4℃保存，长期不使用可以考虑-20℃保存，但冻融可能会导致出现轻微的浑浊和少量不溶物。
Plk1 antibody cell signaling
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WebbDLK1 is a paternally expressed, imprinted gene that plays an important role in normal development and in the maintenence of homeostasis of adipose tissue mass (3). DLK1 … Webb5 mars 2012 · Antibodies for PLK1 (#4535) and Actin (MAB1501) were purchased from Cell Signaling Technology (Danvers, MA) and Millipore, respectively. Secondary …
Webb22 feb. 2024 · The membranes were incubated with specific primary antibodies overnight at 4 °C. Specific primary antibodies against PLK1 (#4513) and Ki67 (ab16667) were … Webb9 jan. 2024 · o Hello. I am currently a biomedical Data Analyst at the Singapore Translational Cancer Consortium, Consortium for Clinical …
Webb10 aug. 2024 · For co-staining with P-CHK1 and PLK1 antibodies: 1.935±0.143 foci/cell from 139 nuclei analyzed for interphasic cells, and 15.680±2.020 foci/cell from 19 nuclei … WebbKévin Adam is the first author on 'A PIM-CHK1 signaling pathway regulates PLK1 phosphorylation and function during mitosis', published in Journal of Cell Science. Kévin conducted the research in this article while a PhD student in the lab of Patrick Mayeux at the Cochin Institute, Paris, France.
WebbWe have previously demonstrated that inhibiting PLK1 causes cell arrest in mitosis, specifically in prophase, ... Cells were stained with the following primary antibodies: Rabbit γ-H2AX (cell signaling, # 9718) and the secondary antibodies: FITC-conjugated donkey anti-rabbit (Jackson Immunoresearch, West Grove, PA, USA).
WebbPolo-like kinase 1 (PLK1) is a serine/threonine kinase that participates in the regulation of various processes, including mitosis, cytokinesis, and the DNA damage response. 4 A number of studies have shown that PLK1 is highly expressed in multiple digestive tumors, such as esophageal cancer, gastric cancer, colorectal cancer, liver cancer, … cherrypickers guide book pdfWebb19 aug. 2024 · Nonetheless, IV-361 has less inhibition on CDK2 (K i ≥1000 nM) or PLK1 (K i ≥5000 nM). In the second place, IV-361 exhibits excellent IL-2 and IL-17 production inhibitory activity (all IC 50 ≤100 nM) in periphery blood mononuclear cells (PBMC). Interestingly, IV-361 exhibits excellent HCT-116 cell growth inhibitory activity (GI 50 ≤100 … flights london to glasgowWebb14 sep. 2024 · These results suggested that Plk1 modulates the migration of tumor cells via STAT3 signaling. Open in a separate ... HeLa cell lysates immunoprecipitated with … cherrypickers guide 6th edition vol 2WebbPLK1 Antibodies Antibodies that detect PLK1 can be used in several scientific applications, including Western Blot, Immunohistochemistry, Immunoprecipitation, … flights london to glasgow airportWebb15 maj 2024 · Rigosertib, via reactive oxygen species (ROS), stimulates cJun N-terminal kinases 1/2 (JNK1/2), which inactivate RAS/RAF signaling and thereby inhibit growth and survival of tumor cells. JNK1/2 are not only regulated by ROS—they in turn can also control ROS production. The prooxidant and cell death function of p66Shc requires … flights london to halifaxWebbThe protein expression data is derived from antibody-based protein profiling using immunohistochemistry. A summary of RNA categories for human tissues, cell lines and … flights london to granada spainWebbThis work identifies PDK1–PLK1-MYC signaling as a new oncogenic pathway driving oncogenic transformation and CSC self-renewal. Targeted inhibition of PDK1/PLK1 is … flights london to ho chi minh city