2024 Sftpb protein function

Sftpb protein function

Author: qjek

August undefined, 2024

Web1 Apr 2024 · We found that only one HDL protein—SFTPB (pulmonary surfactant protein B)—predicted incident CVD in all the models tested. In a fully adjusted model that controlled for lipids and other risk factors, the hazard ratio was 2.17 per SD increase of SFTPB (95% confidence interval, 1.12–4.21, P Supplementary key words SFTPB HDL proteomics … Web18 Nov 2013 · Here, we report on the possible role of circulating pro–surfactant protein B (pro-SFTPB) as a biomarker for early detection of non–small-cell lung cancer (NSCLC). SFTPB is synthesized initially as a hydrophilic 42-kD protein by type 2 alveolar pneumocytes and nonciliated bronchiolar cells as pro-SFTPB.

SFTPB surfactant protein B [ Homo sapiens (human) ]

WebPulmonary Genomics. “A COMPREHENSIVE TEST PANEL TO EVALUATE LUNG FUNCTION”. Genetic pulmonary diseases are respiratory conditions commonly passed down in the genes of generational relations. Some diseases are frequently found in the population and can be managed through drug and lifestyle therapies. An excellent example of this would be … WebTransfection of A549 cells with NKX2-1 expression vectors demonstrated decreased stimulation of SFTPB and SFTPC expression by mutant proteins compared with that of WT. Conclusion: Disruption of transcriptional activation of surfactant protein genes by these DNA-binding domain mutations is a plausible biological mechanism for disruption of … loan consolidation with fair credit

Expression of SFTPB in cancer - Summary - The Human Protein …

WebNX_P07988 - SFTPB - Pulmonary surfactant-associated protein B - Function. Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension … Web14 Mar 2024 · We found that only one HDL protein—SFTPB (pulmonary surfactant protein B)—predicted incident CVD in all the models tested. In a fully adjusted model that controlled for lipids and other risk factors, the hazard ratio was 2.17 per SD increase of SFTPB (95% confidence interval, 1.12–4.21, P = 0.022). Web20:Airway & Pancreas - Proteolysis41:Alveolar cells - Lung function63:Astrocytes - Nervous system maintenance62:B-cells - B-cell activation70:Basal prostatic cells - Lipid … loan conversion rate

SFTPB gene: MedlinePlus Genetics

WebDescription. Surfactant dysfunction is a lung disorder that causes breathing problems. This condition results from abnormalities in the composition or function of surfactant, a … WebSFTPB. CELL LINE. Human cell lines. GENERAL INFORMATIONi. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. loan cookie clickerWeb12 Apr 2024 · Over 40 loss-of-function mutations within SFTPB gene have been identified so far; they result in partial to complete absence of SP-B protein. The most common mutation—a GAA substitution for C at genomic position 1549 in codon 121 (formerly referred to as “121ins2” mutation)—accounts for approximately 70% of cases and results … loan consultant in thane

"WebThis gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for l ung function and homeostasis after birth. Pulmonary … " - Sftpb protein function

Sftpb protein function

WebSFTPB. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. … WebSFTPB. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Official gene symbol, which is typically a short form of the gene name, according to HGNC. Full gene name according to HGNC.

Did you know?

Web22 Jan 2024 · This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. … Web26 Dec 2013 · The mature (and functional) form of surfactant protein B (SFTPB) is approximately 8 kDa in weight and is extremely hydrophobic , . The main function of SFTPB is to accelerate the formation of a surface active film composed of phospholipids at the air-water interface by increasing adsorption rate .

Websftpb. sections. tissue brain single cell type tissue cell type pathology disease immune cell blood protein subcellular ... contact news. news articles press room learn. dictionary protein classes protein evidence methods educational videos data. downloadable data publication data release history sars-cov-2 help. antibody validation ... WebThe hydrophobic surfactant proteins B and C are essential for lung function and pulmonary homeostasis after birth. These proteins enhance the spreading, adsorption, and stability …

Web20:Airway & Pancreas - Proteolysis41:Alveolar cells - Lung function63:Astrocytes - Nervous system maintenance62:B-cells - B-cell activation70:Basal prostatic cells - Lipid … WebSFTPB is part of cluster 19 Lung - Lung function with confidence i Confidence is the fraction of times a gene was assigned to the cluster in repeated clustering, and therefore reflects …

SP-B plays a critical role in the functioning of healthy lungs, and its absence inevitably leads to lung conditions, most common of which being acute respiratory distress syndrome (ARDS). Because of this, SP-B's function has been well researched, and has been found to exist in three parts. Beyond these three functions, it is worth noting that SP-B is also thought to have some anti-inflammatory function, though it is not well defined.

WebSurfactant protein dysfunction syndromes are highly variable in their onset and presentation, and are dependent on the genes involved and environmental factors. This heterogeneous … loan cost origination chargesWeb[9] SFTPB, together with other proteins and phospholipids, creates a barrier on the surface of the alveoli that prevents damage to the alveoli during breathing and is largely generated and secreted by type II cells[10]. The SFTPB gene has been linked to pulmonary illnesses and lung function in earlier research. loan countrywideWeb20:Airway & Pancreas - Proteolysis41:Alveolar cells - Lung function63:Astrocytes - Nervous system maintenance62:B-cells - B-cell activation70:Basal prostatic cells - Lipid metabolism35:Bipolar cells - Visual perception30:Breast - Lactation5:Bronchus - Unknown function77:Cardiomyocytes - Muscle contraction56:Ciliated cells - Cilium … loan cosign nightmare loancor kuilsriverWeb22 Jan 2015 · Plasma pro-surfactant protein B (pro-SFTPB) levels have recently been shown to predict the development of lung cancer in current and ex-smokers, but the ability of pro-SFTPB to predict... indian animal facts for kidsWeb2 Oct 2024 · Surfactant proteins (SP) are involved in surfactant function and innate immunity in the human lung. Both lung function and innate immunity are altered in CF, and altered SP levels and genetic association are observed in Cystic Fibrosis (CF). We hypothesized that single nucleotide polymorphisms (SNPs) within the SP genes associate … indian animation companyWebNX_P07988 - SFTPB - Pulmonary surfactant-associated protein B - Function. Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter. loan credit meaning