WebMar 24, 2024 · How therapies alter this post- translational cancer hallmark and the consequences thereof remain elusive. Here we show that an elevated secretome fucosylation is a pan-cancer signature of both response and resistance to multiple targeted therapies. Large-scale pharmacogenomics revealed that fucosylation genes display … WebThe prognosis and quality of life of HER2 breast cancer patients have significantly improved due to the crucial clinical benefit of various anti-HER2 targeted therapies. However, HER2 tumors can possess or develop several resistance mechanisms to these treatments, thus leaving patients with a limited set of additional therapeutic options. Fortunately, to …
UCLA researchers identify possible approach to prevent cancer …
WebJun 26, 2024 · This is an example of resistance to targeted therapy (in this case estrogen receptor targeted) mediated at the level of chromatin reader/writer complex. In acute myelogenous leukemia (AML), resistance to chemotherapy is regulated in part by EZH2, a H3K27 methyltransferase and a component of the polycomb repressive complex 2. WebA new clinical and preclinical study from UCLA Jonsson Comprehensive Cancer Center identifies the DNA roots of resistance to targeted cancer therapy, providing a possible strategy to address a vexing issue in cancer therapeutics. Results are published online ahead of print in Cancer Discovery, a journal of the American Association for Cancer … florian machard
Drug Resistance - an overview ScienceDirect Topics
WebSep 23, 2024 · However, resistance to targeted therapy eventually occurs. Therefore, it is critical to investigate how HER2-positive breast cancer is resistant to targeted therapy and to develop novel drugs or strategies to overcome the resistance simultaneously. This review aims to provide a comprehensive discussion of the HER2-targeted agents currently in ... WebSep 14, 2015 · The last two decades have witnessed a paradigm shift from cytotoxic drugs to targeted therapy in medical oncology and pharmaceutical innovation. Inspired by … WebJun 1, 2024 · Innate and acquired resistance to KRAS G12C inhibitors has impeded their development and remains an obstacle to their long-term success, as seen with other … greatswords genshin impact