WebJan 16, 2024 · Background Hypercholesterolaemia is common in patients after cardiac transplantation. Monoclonal antibodies that inhibit proprotein convertase subtilisin-kexin … WebOct 16, 2001 · The mechanism of action of TSP1 has been shown to include activation of CD36, p59Fyn, and caspase resulting in apoptosis, as well as activation of transforming …
Thrombospondin-1 regulation of latent TGF-β activation: A …
WebFig. S1. TSP1 is increased in aging human lung vasculature, and TSP1 exposure reduces endothelial cell proliferation. (A) Representative TSP1 abundance in control disease-free … WebMoreover, peptide treatment to block TSP1 binding to its receptor-CD36 attenuated FFA induced podocyte apoptosis, suggesting that TSP1/CD36 interaction mediates FFA … bishops transport forrestfield
Predictive model identifies strategies to enhance TSP1-mediated ...
The thrombospondin-1 protein is a member of the thrombospondin family. It is a multi-domain matrix glycoprotein that has been shown to be a natural inhibitor of neovascularization and tumorigenesis in healthy tissue. Both positive and negative modulation of endothelial cell adhesion, motility, and growth have been attributed to TSP1. This should not be surprising considering that TSP1 interacts with at least 12 cell adhesion receptors, including CD36, αv integrins, β1 integrins, WebJan 10, 2024 · After binding, the CD36-TSP-1 complex activates TGF-β1 to initiate cellular fibrosis . Yang et al. found that CD36 siRNA has antifibrotic effects via the reduction in the … WebThe anti-angiogenic and anti-inflammatory properties of TSP-1 are attributed to the interaction between TSP-1 and CD36. 1. CD47 is another receptor for TSP-1and is expressed by ECs, platelets, erythrocytes, VSMCs, epithelial cells, T-cells, and polymorphonuclear cells. It binds to the C-terminal domain of TSP-1 inducing several, often opposing ... bishop street brunswick ga